Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

QUIN 2 . tetrapotassium salt

Fluorescent probe for Ca2+
ALX-620-006-M005 5 mg 36.00 USD
Do you need bulk/larger quantities?
Calcium specific chelator and indicator. Upon binding calcium there is a shift in the UV spectrum and an enhancement of fluorescence. QUIN 2 was a member of the first generation of Ca2+ chelators introduced by Tsien in 1980. These chelators have backbones similar to that of EGTA (ethylenglycol-bis(β-aminoethyl)-N,N,N',N'-tetraacetic acid) and, like EGTA, they are able to chelate Ca2+ with high affinity and specifity. Moreover, these molecules contain aromatic rings that interact electronically and sterically with the chelating backbone. Thus chelation results in changes in the UV-absorbing and fluorescing properties of the molecules. The resulting spectral changes allow these substances to be used as very sensitive probes for Ca2+ ions, Ca2+ concentrations in single cells of various types can be measured for the first time! TPEN (Prod. No. ALX-450-011) can be used in conjunction with QUIN 2 to reduce heavy-metal quenching of QUIN 2 fluorescence in cells.

Product Specification

Alternative Name:2-[(2-bis-[Carboxymethyl]amino-5-methylphenoxy)-methyl]-6-methoxy-8-bis[carboxymethyl]aminoquinoline . 4K
Formula:C26H23N3O10 . 4K
MW:537.5 . 156.4
MI:14: 8042
Purity:≥95% (HPLC)
Appearance:Yellow powder.
Solubility:Soluble in water.
Long Term Storage:-20°C
Handling:Protect from light.
Please mouse over

Product Literature References

Measurement of the cytosolic free calcium ion concentration of individual lymphocytes by microfluorometry using quin 2 or fura-2: H. Komada, et al.; Cell Struct. Funct. 14, 141 (1989), Abstract;
Quantitation of bovine sperm cytoplasmic calcium with Quin-2 and Fura- 2: evidence that external calcium does not have direct access to the sperm cytoplasm: S. Vijayaraghavan & D. Hoskins; Cell Calcium 10, 241 (1989), Abstract;
Effects of interferon on natural killer (NK) cells assessed by fluorescent probes and flow cytometry: K. McGinnes, et al.; J. Immunol. Meth. 107, 129 (1988), Abstract;
Measurement and manipulation of cytoplasmic free calcium of ram and boar spermatozoa using quin 2: A.M. Simpson & I.G. White; Cell Calcium 9, 45 (1988), Abstract;
Calcium transients in human platelets monitored by aequorin, fura-2 and quin-2: effects of protein kinase C activation and inhibition: P. Erne, et al.; BBRC 145, 66 (1987), Abstract;
Effect of DFP on loading of fura 2/AM and quin 2/AM into single smooth muscle cells prepared from guinea pig taenia coli: I. Maruyama, et al.; FEBS Lett. 220, 89 (1987), Abstract;
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+: P. Arslan, et al.; J. Biol. Chem. 260, 2719 (1985), Abstract; Full Text
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator: R.Y. Tsien, et al.; J. Cell. Biol. 94, 325 (1982), Abstract;

Related Products


Heavy metal chelator
16858-02-9, ≥97% (Nonaqueous Titration) | Print as PDF
ALX-450-011-M100 100 mg 116.00 USD
Do you need bulk/larger quantities?

Related Literature

Product Flyers
Detect Activity of Major ABC Transporter Proteins
Detect Activity of Major ABC Transporter Proteins
Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2018 Enzo Life Sciences, Inc.,