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(S)-ESBA . HCl

Kynurenine aminotransferase inhibitor
ALX-550-529-M001 1 mg 62.00 USD
ALX-550-529-M005 5 mg 245.00 USD
ALX-550-529-M010 10 mg 428.00 USD
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Potent and selective mouse/rat kynurenine aminotransferase II (KAT II) inhibitor. IC50=6.1µM.

Product Specification

Alternative Name:(S)-(4-Ethylsulfonyl)benzoylalanine . hydrochloride
Formula:C12H15NO5S . HCl
MW:285.3 . 36.5
Purity:≥97% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in water or DMSO.
Long Term Storage:-20°C
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Product Literature References

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum: L. Amori, et al.; Neuroscience 159, 196 (2009), Abstract;
Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis: F. Rossi, et al.; Curr. Opin. Struct. Biol. 18, 748 (2008), Abstract;
Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA: R. Pellicciari, et al.; ChemMedChem 3, 1199 (2008), Abstract;
Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid?: R. Schwarcz & C.A. Hunter; Shizophr. Bull. 33, 652 (2007), Abstract; Full Text
Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor: R. Pellicciari, et al.; ChemMedChem 1, 528 (2006), Abstract;

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