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PNU-120596

Nicotinic acetylcholine receptor activator
 
ALX-550-526-M005 5 mg 132.00 USD
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Type II positive allosteric modulator (PAM) of α7 neuronal nicotinic acetylcholine receptor (nAChR) (EC50=216nM). Shows no detectable effect on α4β2, α3β4 and α9α10 receptors.

Product Specification

Alternative Name:NSC 216666, N-(5-Chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)urea
 
Formula:C13H14ClN3O4
 
MW:311.7
 
CAS:501925-31-1
 
Purity:≥98% (HPLC)
 
Identity:Determined by MS and NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (50mg/ml); slightly soluble in methanol (1mg/ml) or acetonitrile (0.5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
550-526
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550-526

Product Literature References

Allosteric Modulators of the alpha7 Nicotinic Acetylcholine Receptor: R. Faghih, et al.; J. Med. Chem. 51, 701 (2008), Abstract;
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes: J.H. Gronlien, et al.; Mol. Pharmacol. 72, 715 (2007), Abstract;
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization: R.S. Hurst, et al.; J. Neurosci. 25, 4396 (2005), Abstract; Full Text

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