R-(+)-Baclofen (free base)

GABA_B receptor agonist



ALX-550-521-M010	10 mg	48.00 USD

ALX-550-521-M050	50 mg	186.00 USD

Selective GABA_B receptor agonist. Skeletal muscle relaxant. The more active enantiomer of (±)-Baclofen (Prod. No. ALX-550-039).

Product Specification

Alternative Name:	R-(+)-β-(Aminoethyl)-4-chlorobenzenepropanoic acid (free base), R-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid (free base)

Formula:	C₁₀H₁₂ClNO₂

MW:	213.7

Purity:	≥98% (NMR, HPLC)

Appearance:	White to off-white powder.

CAS:	69308-37-8

MI:	14: 937

Solubility:	Soluble in 1M HCl (50mg/ml) or DMSO.

Long Term Storage:	+4°C

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Product Literature References

A novel cause of intrathecal baclofen overdosage: lessons to be learnt: C. Dalton, et al.; Clin. Rehabil. 22, 188 (2008), Abstract;

Skeletal muscle relaxants: S. See & R. Ginzburg; Pharmacotherapy 28, 207 (2008), Abstract;

Effects of GABA(B) receptor ligands in animal tests of depression and anxiety: M. Frankowska, et al.; Pharmacol. Rep. 59, 645 (2007), Abstract;

Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat: Y.G. Hong & J.L. Henry; Eur. J. Pharmacol. 196, 267 (1991), Abstract;

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations: E. Flach, et al.; J. Neurochem. 47, 898 (1986), Abstract;

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity: B. Witczuk, et al.; Pol. J. Pharmacol. Pharm. 32, 187 (1980), Abstract;