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JYL-273

TRPV1 agonist
 
ALX-550-390-M001 1 mg 48.00 USD
 
ALX-550-390-M005 5 mg 191.00 USD
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Potent TRPV1 agonist (Ki=11nM). About 500-fold more potent than capsaicin (Prod. No. BML-EI125). RTX binding affinity (Ki=6.35nM), agonism (calcium influx; EC50=2.83nM).

Product Specification

Formula:C28H40N2O4S
 
MW:500.7
 
CAS:289902-71-2
 
Purity:≥98%
 
Appearance:White solid.
 
Solubility:Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
550-390
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Product Literature References

Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 10, 1171 (2002), Abstract;
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 9, 19 (2001), Abstract;

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