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AM 1241

CB2 receptor agonist
 
ALX-550-383-M001 1 mg 40.00 USD
 
ALX-550-383-M005 5 mg 120.00 USD
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Potent and selective CB2 receptor agonist (Ki=3.4nM (mouse), Ki=280nM (rat) also in vivo.

Product Specification

Alternative Name:(2-Iodo-5-nitrophenyl)-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone
 
Formula:C22H22N3O3I
 
MW:503.3
 
CAS:444912-48-5
 
Purity:≥97% (TLC)
 
Identity:Determined by NMR.
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol; insoluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Unstable in 1M NaOH; slightly unstable in 1M HCl.
 
Handling:Protect from light. Packaged under inert gas.
 
550-383
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Product Literature References

Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling: L. Ma, et al.; Biochem. Biophys. Res. Commun. 458, 92 (2015), Application(s): Cell Culture, Abstract;
In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?: B.B. Yao, et al.; Br. J. Pharmacol. 149, 145 (2006), Abstract;
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin: A.G. Hohmann, et al.; J. Pharmacol. Exp. Ther. 308, 446 (2004), Abstract;
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS: M.M. Ibrahim, et al.; PNAS 100, 10529 (2003), Abstract; Full Text
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors: A. Quartilho, et al.; Anesthesiology 99, 955 (2003), Abstract;
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation: A.G. Nackley, et al.; Neuroscience 119, 747 (2003), Abstract;
CB2 cannabinoid receptor-mediated peripheral antinociception: T.P. Malan, Jr., et al.; Pain 93, 239 (2001), Abstract;

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