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MTEP

mGluR5 antagonist
 
ALX-550-381-M005 5 mg 90.00 USD
 
ALX-550-381-M025 25 mg 359.00 USD
Do you need bulk/larger quantities?
 
Potent and highly selective antagonist for mGluR5 with a 5-fold higher anxiolytic activity than MPEP (Prod. No. ALX-550-368). Shows fewer off-target effects than MPEP.

Product Specification

Formula:C11H8N2S
 
MW:200.3
 
CAS:329205-68-7
 
Purity:≥98% (NMR)
 
Identity:Identity determined by 1H-NMR.
 
Appearance:White to yellow solid.
 
Solubility:Soluble in DMSO, 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
550-381
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550-381

Product Literature References

In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP): M.D. Green, et al.; Neurosci. Lett. 391, 91 (2006), Abstract;
MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005), Abstract;
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005), Abstract;
Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005), Abstract;
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004), Abstract;
[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor: N.D. Cosford, et al.; Bioorg. Med. Chem. Lett. 13, 351 (2003), Abstract;
Reduced stress-induced hyperthermia in mGluR5 knockout mice: J. Brodkin, et al.; Eur. J. Neurosci. 16, 2241 (2002), Abstract;
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization: J.J. Anderson, et al.; J. Pharmacol. Exp. Ther. 303, 1044 (2002), Abstract;

Related Products

MPEP . hydrochloride 

mGluR5 antagonist
96206-92-7, ≥99% | Print as PDF
 
ALX-550-368-M005 5 mg 48.00 USD
 
ALX-550-368-M025 25 mg 199.00 USD
Do you need bulk/larger quantities?
 

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