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(Z)-4-Hydroxytamoxifen

Tamoxifen metabolite
 
ALX-550-361-M001 1 mg 53.00 USD
 
ALX-550-361-M005 5 mg 182.00 USD
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Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.

Product Specification

Alternative Name:(Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
 
Formula:C26H29NO2
 
MW:387.5
 
CAS:68047-06-3, 65213-48-1
 
Purity:≥98% (UHPLC)
 
Identity:Determined by 1H-NMR, 13C-NMR and MS.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-550-361
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ALX-550-361

Product Literature References

Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999), Abstract;
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999), Abstract;
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994), Abstract;
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993), Abstract;
Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol: H. Wiseman, et al.; FEBS Lett. 274, 107 (1990), Abstract;
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990), Abstract;

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Tamoxifen . citrate 

PKC inhibitor
54965-24-1, ≥99% (Assay) | Print as PDF
 
ALX-550-095-G001 1 g 111.00 USD
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