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PPAHV

TRPV1 agonist
 
ALX-550-355-M001 1 mg 44.00 USD
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Non-pungent resiniferatoxin-type phorboid vanilloid. Agonist at rat TRPV1 (EC50 between 3 and 10µM) but virtually inactive at human TRPV1 (EC50>10µM). Induces apoptosis through a TRPV-independent mechanism. Tumor promotor.

Product Specification

Alternative Name:Phorbol 12-phenylacetate 13-acetate 20-homovanillate
 
Formula:C39H44O11
 
MW:688.8
 
CAS:175796-50-6
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in methanol, 100% ethanol or DMSO; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-550-355
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ALX-550-355

Product Literature References

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1: E. Phillips, et al.; J. Biol. Chem. 279, 17165 (2004), Abstract;
Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract: comparison of resiniferatoxin with non-pungent agents and anandamide: D.P. Geraghty, et al.; Br. J. Pharmacol. 137, 919 (2002), Abstract;
Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists: J.S. Shin, et al.; Neurosci. Lett. 299, 135 (2001), Abstract;
Pharmacological differences between the human and rat vanilloid receptor 1 (VR1): P. McIntyre, et al.; Br. J. Pharmacol. 132, 1084 (2001), Abstract;
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology: J.C. Jerman, et al.; Br. J. Pharmacol. 130, 916 (2000), Abstract;
Functional and desensitizing effects of the novel synthetic vanilloid- like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb: C.D. Griffiths, et al.; Br. J. Pharmacol. 131, 1408 (2000), Abstract;
Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism: A. Macho, et al.; Chem. Biol. 7, 483 (2000), Abstract;
A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons: L. Liu, et al.; Neuroscience 84, 569 (1998), Abstract;
A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor: A. Szallasi, et al.; Eur. J. Pharmacol. 299, 221 (1996), Abstract;
Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity: G. Appendino, et al.; J. Med. Chem. 39, 3123 (1996), Abstract;

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