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PPADS . tetrasodium salt

P2 purinergic receptor antagonist
 
ALX-550-347-M010 10 mg 35.00 USD
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Selective P2 purinoceptor antagonist which blocks responses at both pre- and postjunctional sites.

Product Specification

Alternative Name:Pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid . 4Na
 
Formula:C14H10N3O12PS2 . 4Na
 
MW:507.3 . 92.0
 
CAS:192575-19-2
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR
 
Appearance:Orange solid.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Hygroscopic.
 
ALX-550-347
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ALX-550-347

Product Literature References

Discrimination by PPADS between endothelial P2Y- and P2U-purinoceptors in the rat isolated mesenteric arterial bed: V. Ralevic & G. Burnstock; Br. J. Pharmacol. 118, 428 (1996), Abstract;
Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase: M. Picher, et al.; Biochem. Pharmacol. 51, 1453 (1996), Abstract;
PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors: S.J. Charlton, et al.; Br. J. Pharmacol. 118, 704 (1996), Abstract;
PPADS: an antagonist at the endothelial P2Y-purinoceptors but not P2U-purinoceptors: C. Brown, et al.; Br. J. Pharmacol. 116, 2413 (1995), Abstract;
Investigation of the actions of PPADS, a novel P2X-purinoceptor antagonist, in the guinea-pig isolated vas deferens: G.J. MacLaren, et al.; Br. J. Pharmacol. 111, 913 (1994), Abstract;
Selective antagonism by PPADS at P2X-purinoreceptors in rabbit isolated blood vessels: A.U. Ziganshin, et al.; Br. J. Pharmacol. 111, 923 (1994), Abstract;
PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder: A.U. Ziganshin, et al.; Br. J. Pharmacol. 110, 1491 (1993), Abstract;
PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses: G. Lambrecht, et al.; Eur. J. Pharmacol. 217, 217 (1992), Abstract;

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