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Cyclothiazide

AMPA receptor activator
 
ALX-550-338-M050 50 mg 198.00 USD
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Potently inhibits the desensitization of AMPA receptors. Antihypertensive.

Product Specification

Alternative Name:3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-3,4-dihydro-3[2-norbornen-5-yl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 
Formula:C14H16ClN3O4S2
 
MW:389.9
 
CAS:2259-96-3
 
MI:14: 2754
 
Purity:≥98% (HPLC (UV))
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO, methanol (36mg/ml) or dilute aqueous base (36mg/ml); insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-550-338
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ALX-550-338

Product Literature References

Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure: H. O'Leary, et al. ; Neurobiol. Dis. 87, 134 (2015), Application(s): Blocked AMPAR desensitization, Abstract;
Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists: M.A. Desai, et al.; J. Pharmacol. Exp. Ther. 272, 38 (1995), Abstract;
Inhibition by cyclothiazide of neuronal nicotinic responses in bovine chromaffin cells: J.M. Nooney & A. Feltz; Br. J. Pharmacol. 114, 648 (1995), Abstract;
Modulation of AMPA/kainate receptors by cyclothiazide increases cytoplasmic free Ca2+ and 45Ca2+ uptake in brain neurons: G. Cebers & S. Liljequist; Eur. J. Pharmacol. 290, 105 (1995), Abstract;
Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes: R.L. Sharp, et al.; Eur. J. Pharmacol. 266, R1 (1994), Abstract;
Desensitization of AMPA receptors upon multiquantal neurotransmitter release: L.O. Trussell, et al.; Neuron 10, 1185 (1993), Abstract;
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors: L.A. Wong & M.L. Mayer; Mol. Pharmacol. 44, 504 (1993), Abstract;

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