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(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine

mGluR antagonist
 
ALX-550-333-M001 1 mg 30.00 USD
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Selective group II mGluR antagonist.

Product Specification

Alternative Name:MCCG, α-Methyl-L-CCG I
 
Formula:C7H11NO4
 
MW:173.2
 
CAS:157141-16-7
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white crystalline powder.
 
Solubility:Soluble to 50mM in 1 eq. of NaOH or dilute aqueous base.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-550-333
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ALX-550-333

Product Literature References

Attenuation of morphine withdrawal symptoms by subtype-selective metabotropic glutamate receptor antagonists: M.E. Fundytus, et al.; Br. J. Pharmacol. 120, 1015 (1997), Abstract;
Metabotropic glutamate receptor antagonists, like GABA(B) antagonists, potentiate dorsal root-evoked excitatory synaptic transmission at neonatal rat spinal motoneurons in vitro: C.Q. Cao, et al.; Neuroscience 78, 243 (1997), Abstract;
Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices: M.C. Kemp, et al.; Eur. J. Pharmacol. 309, 79 (1996), Abstract;
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996), Abstract;
Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel alpha-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamu: T.E. Salt & S.A. Eaton; Neuroscience 65, 5 (1995), Abstract;
Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes: T. Knöpfel, et al.; Neuropharmacology 34, 1099 (1995), Abstract;
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord: D.E. Jane, et al.; Br. J. Pharmacol. 112, 809 (1994), Abstract;

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