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S-(+)-CBPG

mGluR antagonist
 
ALX-550-323-M001 1 mg 35.00 USD
 
ALX-550-323-M005 5 mg 133.00 USD
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Potent and selective group I mGluR antagonist.

Product Specification

Alternative Name:S-(+)-2-(3'-Carboxybicyclo[1.1.1]pentyl)glycine, UPF 596
 
Formula:C8H11NO4
 
MW:185.2
 
Purity:≥95% (1H-NMR)
 
Appearance:White solid.
 
Solubility:Soluble in water or DMSO.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-550-323
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Product Literature References

1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'- carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral: D.E. Pellegrini-Giampietro, et al.; Eur. J. Neurosci. 11, 3637 (1999), Abstract;
Biochemical and electrophysiological studies on (S)-(+)-2-(3'- carboxybicyclo[1.1.1]pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity: G. Mannaioni, et al.; Neuropharmacology 38, 917 (1999), Abstract;
Metabotropic G-protein-coupled glutamate receptors as therapeutic targets: R. Pellicciari & G. Costantino; Curr. Opin. Chem. Biol. 3, 433 (1999), (Review), Abstract;
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract;
Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms: D.E. Pellegrini-Giampietro, et al.; Neuropharmacology 38, 1607 (1999), Abstract;
Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex: F. Moroni, et al.; Eur. J. Pharmacol. 347, 189 (1998), Abstract;
(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist: R. Pellicciari, et al.; J. Med. Chem. 39, 2874 (1996), Abstract;
Pharmacological studies on new agonists and antagonists of mGluRs: R. Pellicciari, et al.; Neuropharmacology 35, A21 (1996),

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