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mGluR antagonist
ALX-550-311-M001 1 mg 62.00 USD
ALX-550-311-M005 5 mg 246.00 USD
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Selective group II mGluR antagonist.

Product Specification

Alternative Name:(2S,1'S,2'S,3'R)-2-(2'Carboxy-3'-phenylcyclopropyl)glycine
Appearance:White solid.
Solubility:Soluble in DMSO; poorly soluble in water.
Long Term Storage:+4°C
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Product Literature References

Metabotropic G-protein-coupled glutamate receptors as therapeutic targets: R. Pellicciari & G. Costantino; Curr. Opin. Chem. Biol. 3, 433 (1999), (Review), Abstract;
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), Abstract;
Roles of metabotropic glutamate receptor subtypes in modulation of pentylenetetrazole-induced seizure activity in mice: C. Thomsen & N.O. Dalby; Neuropharmacology 37, 1465 (1998), Abstract;
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death: G. Battaglia, et al.; Eur. J. Pharmacol. 356, 271 (1998), Abstract;
Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture: R. Ciccarelli, et al.; Glia 21, 390 (1997), Abstract;
PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro: L. Huang, et al.; Eur. J. Pharmacol. 332, 161 (1997), Abstract;
The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling: V. Bruno, et al.; J. Neurosci. 17, 1891 (1997), Abstract;
Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist: A. Cozzi, et al.; Eur. J. Neurosci. 9, 1350 (1997), Abstract;
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors: C. Thomsen, et al.; Mol. Pharmacol. 50, 6 (1996), Abstract;
Asymmetric synthesis of enantiomerically pure (2S,1'S,2'S,3'R)-phenylcarboxycyclopropylglycine (PCCG-4): a potent and selective ligand at group II metabotropic glutamate receptors: M. Marinozzi, et al.; Bioorg. Med. Chem. Lett. 6, 2243 (1996),
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptor: R. Pellicciari, et al.; J. Med. Chem. 39, 2259 (1996), Abstract;

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