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Trifluoperazine . dihydrochloride

Antipsychotic
 
ALX-550-310-G001 1 g 36.00 USD
 
ALX-550-310-G005 5 g 109.00 USD
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Replaces Prod. #: BML-CA310

Facilitates agonist induced elevation of cytosolic calcium at low concentrations (10µM). Antagonizes calmodulin at higher concentrations. Antipsychotic and sedative dopamine antagonist. Potent and irreversible inhibitor of cAMP-gated cationic channels. Inhibits DNA repair. Cell permeable. Potent neurotoxin.

Product Specification

Formula:C21H24F3N3S . 2HCl
 
MW:407.5 . 73.0
 
CAS:440-17-5
 
MI:14: 9680
 
RTECS:SP1750000
 
Purity:≥98% (UPLC)
 
Identity:Identity determined by IR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 
550-310
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550-310

Product Literature References

The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death: A.G. Polischouk, et al.; Mol. Cancer Ther. 6, 2303 (2007), Abstract;
Trifluoperazine protects brain plasma membrane Ca(2+)-ATPase from oxidative damaging: P. Souza dos Santos, et al.; Exp. Brain Res. 177, 347 (2007), Abstract;
Trifluoperazine stimulates ionizing radiation induced cell killing through inhibition of DNA repair: S. Gangopadhyay, et al.; Mutat. Res. 633, 117 (2007), Abstract;
Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor: P.L. Sheets, et al.; J. Neurophysiol. 96, 1848 (2006), Abstract;
Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists: S.J. Kleene; Br. J. Pharmacol. 111, 469 (1994), Abstract;
Trifluoperazine-induced conformational change in Ca(2+)-calmodulin: M. Vandonselaar, et al.; Nat. Struct. Biol. 1, 795 (1994), Abstract;
Trifluoperazine binding to porcine brain calmodulin and skeletal muscle troponin C: J. Massom, et al.; Biochemistry 29, 671 (1990), Abstract;
Influence of calmodulin antagonist (stelazine) on agonist-induced calcium mobilization and platelet activation: G.H. Rao; BBRC 148, 768 (1987), Abstract;
New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme): H.L. Macfie, et al.; Drug Intel. Clin. Pharm. 15, 94 (1981), Abstract;

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