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JYL-79

TRPV1 agonist
 
ALX-550-296-M001 1 mg 55.00 USD
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Potent TRPV1 agonist (Ki=19nM). About 300-fold more potent than capsaicin (Prod. No. BML-EI125). RTX binding affinity (Ki=17.4nM), agonism (calcium influx; EC50=1.97nM).

Product Specification

Alternative Name:2-(3,4-Dimethylbenzyl)-3-{[(4-hydroxy-3-methoxy-benzyl)amino]carbothioyl}propyl pivalate, Vanilloid Receptor Agonist 23
 
Formula:C26H36N2O4S
 
MW:472.6
 
Purity:≥98%
 
Appearance:Off-white to yellow sticky solid.
 
Solubility:Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
550-296
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550-296

Product Literature References

Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 10, 1171 (2002), Abstract;
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 9, 19 (2001), Abstract;

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Capsaicin 

TRPV1 agonist
404-86-4, Isolated from Capsicum  fruit., ≥98% (TLC) | Print as PDF
 
BML-EI125-0200 200 mg 109.00 USD
 
BML-EI125-1000 1 g 420.00 USD
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