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Nimodipine

Ca2+ channel inhibitor
 
ALX-550-277-G001 1 g 228.00 USD
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Replaces Prod. #: BML-CA211

Ca2+ channel antagonist. Highly potent at L-type channels. Block some low-voltage activated Ca2+ channels. Enhances memory in old or brain-damaged animals. Ameliorates experimental diabetic neuropathy in streptozotocin-induced diabetic rats. Vasodilator.

Product Specification

Alternative Name:1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl ester
 
Formula:C21H26N2O7
 
MW:418.4
 
CAS:66085-59-4
 
MI:14: 6551
 
Purity:≥99% (Assay)
 
Appearance:Yellowish crystalline powder.
 
Solubility:Soluble in DMSO (25mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
550-277
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550-277

Product Literature References

Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer: A.C. Kappelle, et al.; Br. J. Pharmacol. 111, 887 (1994), Abstract;
Amelioration by the Ca2+ antagonist, nimodipine of an existing neuropathy in the streptozotocin-induced, diabetic rat: A.C. Kappelle, et al.; Br. J. Pharmacol. 108, 780 (1993), Abstract;
Low-voltage activated calcium channels are differently affected by nimodipine: A. Formenti, et al.; Neuroreport 5, 145 (1993), Abstract;
New uses for calcium channel blockers. Therapeutic implications: M. Fisher & J. Grotta; Drugs 46, 961 (1993), Abstract;
Multiple types of high-threshold calcium channels in rabbit sensory neurons: high-affinity block of neuronal L-type by nimodipine: R.T. McCarthy and P.E. TanPiengco; J. Neurosci. 12, 2225 (1992), Abstract;
Nimodipine and the recovery of memory: I. Izquierdo; TIPS 11, 309 (1990), Abstract;
1,4-Dihydropyridine activators and antagonists: structural and functional distinctions: D.J. Triggle & D. Rampe; TIPS 10, 507 (1989), Abstract;
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine: S.J. Dolin, et al.; Eur. J. Pharmacol. 152, 19 (1988), Abstract;

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