8-Cyclopentyl-1,3-dipropylxanthine

A₁ adenosine receptor antagonist



ALX-550-269-M010	10 mg	23.00 USD

Potent and very selective A₁ adenosine receptor antagonist, both in vitro and in vivo.

Product Specification

Alternative Name:	DPCPX, PD 116,948, 1,3-Dipropyl-8-cyclopentylxanthine

Formula:	C₁₆H₂₄N₄O₂

MW:	304.4

Purity:	≥98% (HPLC)

Appearance:	White to light yellow.

CAS:	102146-07-6

Solubility:	Soluble in 100% ethanol or DMSO; insoluble in water.

Long Term Storage:	+20°C

Hazard:	IRRITANT.

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Product Literature References

Characterization of the adenosine receptors mediating hypothermia in the conscious mouse: Anderson, et al.; Br. J. Pharmacol. 113, 1386 (1994), Abstract;

Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations: H. von der Leyen, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 204 (1989), Abstract;

Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3- dipropylxanthine to rat brain membranes: R.F. Bruns, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 59 (1987), Abstract;

PD 116,948, a highly selective A1 adenosine receptor antagonist: S.J. Haleen, et al.; Life Sci. 40, 555 (1987), Abstract;

1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N- ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors: K.S. Lee & M. Reddington; Brain Res. 368, 394 (1986), Abstract;