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Flunarizine . dihydrochloride

Ca2+ channel inhibitor
 
ALX-550-268-G001 1 g 46.00 USD
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Replaces Prod. #: BML-CA225

Selectively blocks the low threshold (T-type) calcium channel in rat hippocampal CA1 pyramidal neurons. Inhibits Ca2+-influx-induced vasoconstriction of peropheral and cerebral blood vessels with little effect on myogenic activity and Ca2+-depenent myocardial contractility.

Product Specification

Alternative Name:1-[bis(4-Fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine . 2HCl
 
Formula:C26H26F2N2 . 2HCl
 
MW:404.5 . 72.9
 
CAS:30484-77-6
 
MI:14: 4144
 
Purity:≥99% (HPLC)
 
Identity:Determined by IR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml), 100% ehanol (5mg/ml) or chloroform:methanol (1:1; 50mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-550-268
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ALX-550-268

Product Literature References

Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal CA1 pyramidal neurons: K. Takahashi & . Akaike; J. Pharmacol. Exp. Ther. 256, 169 (1991), Abstract;
Calcium antagonism and calcium entry blockade: T. Godfraind et al.; Pharmacol. Rev. 38, 321 (1986), Abstract;
Platelet-mediated vascular contractions. Inhibition by flunarizine, a calcium-entry blocker: F. De Clerck & J.M. Van Nueten ; Biochem. Pharmacol. 32, 765 (1983), Abstract;

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