R-(+)-DIOA

K⁺ channel blocker



ALX-550-263-M005	5 mg	42.00 USD

ALX-550-263-M025	25 mg	152.00 USD

Inhibitor of the K⁺/Cl^--cotransport that does not affect the bumetanide-sensitive Na⁺/K⁺/Cl^--cotransport system.

Product Specification

Alternative Name:	R-(+)-Butylindazone, (Dihydroindenyl)oxy alkanoic acid

Formula:	C₂₀H₂₄Cl₂O₄

MW:	399.3

Purity:	≥98%

Appearance:	White solid.

CAS:	81166-47-4

Solubility:	Soluble in 100% ethanol or dilute aqueous base; insoluble in water or dilute aqueous acid.

Long Term Storage:	+20°C

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Product Literature References

Demonstration of a [K+,Cl-]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive [Na+,K+,Cl- ]-cotransport system: R.P. Garay, et al.; Mol. Pharmacol. 33, 696 (1988), Abstract;

The significance of the relative effects of loop diuretics and anti-brain edema agents on the Na+,K+,Cl- cotransport system and the Cl-/NaCO3- anion exchanger: R.P. Garay, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 334, 202 (1986), Abstract;