Amiloride, 5-(N,N-Dimethyl)-, . hydrochloride

Na⁺/H+ antiporter inhibitor



ALX-550-261-M005	5 mg	29.00 USD

Na/Hantiporter inhibitor (IC₅₀=6.9 µM) with increased selectivity and potency relative to amiloride (Prod. No. ALX-550-212).

Product Specification

Alternative Name:	5-(N,N-Dimethyl)amiloride . HCl, DMA . HCl

Formula:	C₈H₁₂ClN₇O . HCl

MW:	257.7 . 36.5

Purity:	≥98%

Appearance:	Yellow solid.

CAS:	1214-79-5 (free base)

Solubility:	Soluble in methanol (10mg/ml) or water (6mg/ml).

Long Term Storage:	+4°C

Hazard:	IRRITANT.

Handling:	Protect from light.

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Product Literature References

Effect of 5-(N,N-Dimethyl)-amiloride, a specific inhibitor of Na(+)/H(+) exchanger, on the palmitoyl-L-carnitine-induced mechanical and metabolic derangements in the isolated perfused rat heart: J. Arakawa & A. Hara; Pharmacology 59, 239 (1999), Abstract;

Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger: L. Mirossay, et al.; Physiol. Res. 48, 135 (1999), Abstract;

Involvement of sodium in the protective effect of 5-(N,N-dimethyl)- amiloride on ischemia-reperfusion injury in isolated rat ventricular wall: H. Meng & G.N. Pierce; J. Pharmacol. Exp. Ther. 256, 1094 (1991), Abstract;

Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman & E.J. Cragoe Jr.; J. Membr. Biol. 105, 1 (1988), Abstract;