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Amiloride, 5-(N,N-Dimethyl)-, . hydrochloride

Na+/H+ antiporter inhibitor
 
ALX-550-261-M005 5 mg 53.00 USD
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Na+/H+ antiporter inhibitor (IC50=6.9 µM) with increased selectivity and potency relative to amiloride (Prod. No. ALX-550-212).

Product Specification

Alternative Name:5-(N,N-Dimethyl)amiloride . HCl, DMA . HCl
 
Formula:C8H12ClN7O . HCl
 
MW:257.7 . 36.5
 
CAS:1214-79-5 (free base)
 
Purity:≥97% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in methanol (10mg/ml) or water (6mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-550-261
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ALX-550-261

Product Literature References

Effect of 5-(N,N-Dimethyl)-amiloride, a specific inhibitor of Na(+)/H(+) exchanger, on the palmitoyl-L-carnitine-induced mechanical and metabolic derangements in the isolated perfused rat heart: J. Arakawa & A. Hara; Pharmacology 59, 239 (1999), Abstract;
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger: L. Mirossay, et al.; Physiol. Res. 48, 135 (1999), Abstract;
Involvement of sodium in the protective effect of 5-(N,N-dimethyl)- amiloride on ischemia-reperfusion injury in isolated rat ventricular wall: H. Meng & G.N. Pierce; J. Pharmacol. Exp. Ther. 256, 1094 (1991), Abstract;
Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman & E.J. Cragoe Jr.; J. Membr. Biol. 105, 1 (1988), Abstract;

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