Diazoxide

K⁺ channel activator



ALX-550-260-M500	500 mg	49.00 USD

ALX-550-260-G001	1 g	78.00 USD

Replaces Prod. #: BML-KC115

ATP-sensitive K⁺channel activator. Effective concentrations in patch clamp experiments: 100-600µM. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.

Product Specification

Alternative Name:	7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Formula:	C₈H₇ClN₂O₂S

MW:	230.7

Purity:	≥98%

Appearance:	White to off-white powder.

CAS:	364-98-7

MI:	14: 3004

RTECS:	DK8185000

Solubility:	Soluble in DMSO (25mg/ml); insoluble in water.

Long Term Storage:	+4°C

Hazard:	HARMFUL.

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Product Literature References

Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells: C. Schwanstecher, et al.; Br. J. Pharmacol. 107, 87 (1992), Abstract;

Block of ATP-regulated potassium channels by phentolamine and other alpha-adrenoceptor antagonists: M.J. Dunne et al.; Br. J. Pharmacol. 103, 1847 (1991), Abstract;

Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells: M.J. Dunne, et al.; J. Membr. Biol. 114, 53 (1990), Abstract;

The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim: D.T. Newgreen, et al.; Br. J. Pharmacol. 100, 605 (1990), Abstract;

In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide: U. Quast & N.S. Cook; J. Pharmacol. Exp. Ther. 250, 261 (1989), Abstract;

Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells: M.J. Dunne; FEBS Lett. 250, 262 (1989), Abstract;

Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line: N.C. Strugess et al.; Br. J. Pharmacol. 95, 83 (1988), Abstract;

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells: G. Trube, et al.; Pflugers Arch. Eur. J. Physiol. 407, 493 (1986), Abstract;

The Merck Index: 12, 3051 (0),