Amiloride, 5-(N-Methyl-N-isobutyl)-

Na⁺/H+ antiporter inhibitor



ALX-550-257-M005	5 mg	16.00 USD

Potent inhibitor of the Na/H antiporter. Possible antitumor agent.

Product Specification

Formula:	C₁₁H₁₈ClN₇O

MW:	299.8

Purity:	≥98%

Appearance:	Yellow solid.

CAS:	96861-65-3

Solubility:	Soluble in dilute aqueous acid or DMSO; insoluble in water.

Long Term Storage:	+4°C

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Product Literature References

Methyl isobutyl amiloride alters regional brain reperfusion after resuscitation from cardiac arrest in rats: K.L. Lauro, et al.; Brain Res. 831, 64 (1999), Abstract;

Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart: X.H. Xiao & D.G. Allen; Circ. Res. 85, 723 (1999), Abstract;

Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC: I.Y. Novikova, et al.; Biochim. Biophys. Acta 1178, 267 (1993), Abstract;

Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy: R.P. Maidorn, et al.; Br. J. Cancer. 67, 297 (1993), Abstract;

Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters: Z. Talor, et al.; Life Sci. 45, 517 (1989), Abstract;

Interactions of chloride and amiloride with the renal Na+/H/ antiporter: D.G. Warnock, et al.; J. Biol. Chem. 263, 7216 (1988), Abstract; Full Text