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R-(+)-IAA-94

Cl- channel blocker
 
ALX-550-248-M005 5 mg 61.00 USD
 
ALX-550-248-M025 25 mg 239.00 USD
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Replaces Prod. #: BML-CM101

Potent mammalian skeletal muscle and epithelial chloride channel blocker (Ki=1μM in bovine kidney cortex microsomes). May be used to assay, enrich and characterize skeletal muscle chloride channels.

Product Specification

Alternative Name:R-(+)-Methylindazone, Indanyloxyacetic acid 94, R-(+)-[(6,7-Dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]acetic acid
 
Formula:C17H18Cl2O4
 
MW:357.2
 
CAS:54197-31-8
 
Purity:≥98% (HPLC)
 
Identity:Identity determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
ALX-550-248
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ALX-550-248

Product Literature References

Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria: A. A. Gerencser, et. al.; J. Physiol. 590, 2845 (2012), Abstract; Full Text
Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle: S. Weber-Schurholz, et al.; J. Biol. Chem. 268, 547 (1993), Abstract; Full Text
Contribution of Ca and Ca-activated Cl channels to regenerative depolarization and membrane bistability of cone photoreceptors: S. Barnes & M.C. Deschenes; J. Neurophysiol. 68, 745 (1992), Abstract;
Purification and reconstitution of chloride channels from kidney and trachea: D.W. Landry, et al.; Science 244, 1469 (1989), Abstract;
Epithelial chloride channel. Development of inhibitory ligands: D.W. Landry, et al.; J. Gen. Physiol. 90, 779 (1987), Abstract;

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