R-(+)-IAA-94

Cl^- channel blocker



ALX-550-248-M005	5 mg	52.00 USD

ALX-550-248-M025	25 mg	206.00 USD

Replaces Prod. #: BML-CM101

Potent mammalian skeletal muscle and epithelial chloride channel blocker (K_i=1μM in bovine kidney cortex microsomes). May be used to assay, enrich and characterize skeletal muscle chloride channels.

Product Specification

Alternative Name:	R-(+)-Methylindazone, Indanyloxyacetic acid 94, R-(+)-[(6,7-Dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]acetic acid

Identity:	Identity determined by NMR.

Formula:	C₁₇H₁₈Cl₂O₄

MW:	357.2

Purity:	≥98% (HPLC)

Appearance:	White solid.

CAS:	54197-31-8

Solubility:	Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).

Long Term Storage:	+20°C

Please mouse over

Product Literature References

Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle: S. Weber-Schurholz, et al.; J. Biol. Chem. 268, 547 (1993), Abstract; Full Text

Contribution of Ca and Ca-activated Cl channels to regenerative depolarization and membrane bistability of cone photoreceptors: S. Barnes & M.C. Deschenes; J. Neurophysiol. 68, 745 (1992), Abstract;

Purification and reconstitution of chloride channels from kidney and trachea: D.W. Landry, et al.; Science 244, 1469 (1989), Abstract;

Epithelial chloride channel. Development of inhibitory ligands: D.W. Landry, et al.; J. Gen. Physiol. 90, 779 (1987), Abstract;