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Aconitine

Na+ channel activator
 
ALX-550-232-M025 25 mg 34.00 USD
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A lipid-soluble neurotoxin that acts as a sodium channel modulator. Binds with high affinity to the open state of the voltage-sensitive sodium channels at site 2, thereby causing a persistent activation of the sodium channels, which become refractory to excitation.

Product Specification

Alternative Name:(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate
 
Formula:C34H47NO11
 
MW:645.7
 
Source:Isolated from Aconitum karacolium.
 
CAS:302-27-2
 
MI:14: 118
 
RTECS:AR5960000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in 100% ethanol (35mg/ml); almost insoluble in water (0.3mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-550-232
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ALX-550-232

Product Literature References

Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine: S.P. Yu & W. Van der Kloot; Neurosci. Lett. 117, 111 (1990), Abstract;
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids: M. Muroi, et al.; Neuropharmacology 29, 567 (1990), Abstract;

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