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FPL 64176

Ca2+ channel activator
 
ALX-550-229-M005 5 mg 77.00 USD
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Replaces Prod. #: BML-CA245

A potent L-type Ca2+ channel opener. Induces a contractile response in cardiac and vascular smooth muscle, EC50=0.2µM.

Product Specification

Alternative Name:2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
 
Formula:C22H21NO3
 
MW:347.4
 
CAS:120934-96-5
 
Purity:≥98%
 
Appearance:White to tan powder.
 
Solubility:Soluble in 100% ethanol (2mg/ml) or DMSO (10mg/ml); insoluble in aqueous solution.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light. Hygroscopic.
 
ALX-550-229
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ALX-550-229

Product Literature References

Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176: D. Rampe, et al.; J. Pharmacol. Exp. Ther. 265, 1125 (1993), Abstract;
A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176: D. Rampe & A.E. Lacerda; J. Pharmacol. Exp. Ther. 259, 982 (1991), Abstract;
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations: W. Zheng, et al.; Mol. Pharmacol. 40, 734 (1991), Abstract;

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Calcium channel
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