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5-Nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione

NMDA receptor antagonist
 
ALX-550-228-M005 5 mg 105.00 USD
 
ALX-550-228-M025 25 mg 432.00 USD
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Potent and selective NMDA receptor glycine site antagonist.

Product Specification

Alternative Name:ACEA-1021
 
Formula:C8H3Cl2N3O4
 
MW:276.0
 
CAS:153504-81-5
 
Purity:≥98% (TLC; elemental analysis)
 
Appearance:Yellow powder.
 
Solubility:Soluble in DMSO or dilute aqueous base.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-550-228
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Product Literature References

In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D- aspartate receptor glycine sites: R.M. Woodward, et al.; Mol. Pharmacol. 47, 568 (1995), Abstract;
Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3- quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist: R.M. Woodward, et al.; J. Pharmacol. Exp. Ther. 275, 1209 (1995), Abstract;
Synthesis and structure-activity relationships of substituted 1,4- dihydroquinoxaline-2,3-diones: antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors: J.F.W. Keana, et al.; J. Med. Chem. 38, 4367 (1995), Abstract;

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