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Amiloride . hydrochloride . dihydrate

Ca2+ channel inhibitor
 
ALX-550-212-G001 1 g 40.00 USD
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Replaces Prod. #: BML-CA200

Selectively blocks low threshold (T-type) calcium channel (KD=30μM) with no effect on L-type channels or tetrodotoxin Na+ channels. Inhibits the epithelial tetrodotoxin insensitive Na+ channel (IC50 =1μM). Clinically useful K+ sparing diuretic.

Product Specification

Alternative Name:3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide . HCl . 2H2O
 
Formula:C6H8ClN7O . HCl . 2H2O
 
MW:229.6 . 36.5 . 36.0
 
CAS:17440-83-4
 
Purity:≥98% (HPLC)
 
Appearance:Light yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml) or water (1mg/ml warm).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Inhibitory effects of amiloride and its analogues on prostaglandin E2-stimulated fluid transport by cultured porcine thyroid cells: evidence for apical membrane Na+ channels: T. Matainaho, et al.; J. Endocrinol. 123, 93 (1989), Abstract;
Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman and E.J. Kragoe Jr.; J. Membr. Biol. 105, 1 (1988), Abstract;
Amiloride selectively blocks the low threshold (T) calcium channel: C.-M. Tang, et al.; Science 240, 213 (1988), Abstract;
The amiloride-sensitive sodium channel: S. Sariban-Sohraby & D.J. Benos; Am. J. Physiol. 250, C175 (1986), Abstract;
New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme): H.L. Macfie, et al.; Drug Intell. Clin. Pharm. 15, 94 (1981), Abstract;

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