Amiloride . hydrochloride . dihydrate

Ca²⁺ channel inhibitor



ALX-550-212-G001	1 g	36.00 USD

Replaces Prod. #: BML-CA200

Selectively blocks low threshold (T-type) calcium channel (K_D=30μM) with no effect on L-type channels or tetrodotoxin Na⁺ channels. Inhibits the epithelial tetrodotoxin insensitive Na⁺ channel (IC₅₀ =1μM). Clinically useful K⁺ sparing diuretic.

Product Specification

Alternative Name:	3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide . HCl . 2H₂O

Formula:	C₆H₈ClN₇O . HCl . 2H₂O

MW:	229.6 . 36.5 . 36.0

Purity:	≥98%

Appearance:	Light yellow solid.

CAS:	17440-83-4

Solubility:	Soluble in DMSO (25mg/ml) or water (1mg/ml warm).

Long Term Storage:	+20°C

Hazard:	TOXIC.

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Product Literature References

Inhibitory effects of amiloride and its analogues on prostaglandin E2-stimulated fluid transport by cultured porcine thyroid cells: evidence for apical membrane Na+ channels: T. Matainaho, et al.; J. Endocrinol. 123, 93 (1989), Abstract;

Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman and E.J. Kragoe Jr.; J. Membr. Biol. 105, 1 (1988), Abstract;

Amiloride selectively blocks the low threshold (T) calcium channel: C.-M. Tang, et al.; Science 240, 213 (1988), Abstract;

The amiloride-sensitive sodium channel: S. Sariban-Sohraby & D.J. Benos; Am. J. Physiol. 250, C175 (1986), Abstract;

New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme): H.L. Macfie, et al.; Drug Intell. Clin. Pharm. 15, 94 (1981), Abstract;