Potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations.
Product Details
| Alternative Name: | SYM 2081 |
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| Formula: | C6H11NO4 |
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| MW: | 161.2 |
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| CAS: | 31137-74-3 |
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| Purity: | ≥97% |
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| Appearance: | White powder. |
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| Solubility: | Soluble in dilute aqueous acid. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia: M.S. Turner, et al.; Brain Res.
973, 252 (2003),
Abstract;
(2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors: L.M. Zhou, et al.; J. Pharmacol. Exp. Ther.
280, 422 (1997),
Abstract;
Full Text
Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors: Z.Q. Gu, et al.; J. Med. Chem.
38, 2518 (1995),
Abstract;
Glutamate uptake system in the presynaptic vesicle: glutamic acid analogs as inhibitors and alternate substrates: H.C. Winter & T. Ueda; Neurochem. Res.
18, 79 (1993),
Abstract;
