Gallamine triethiodide

Muscarinic acetylcholine receptor M2 antagonist



ALX-550-180-M500	500 mg	10.00 USD

Replaces Prod. #: BML-C112

M₂muscarinic receptor antagonist with pronounced cardioselectivity. Acts via allosteric modulation of preceptor binding.

Product Specification

Formula:	C₃₀H₆₀N₃O₃I₃

MW:	891.5

Appearance:	White to off-white solid.

CAS:	65-29-2

MI:	14: 4343

RTECS:	BS1100000

Solubility:	Soluble in water (25mg/ml) or 100% ethanol.

Long Term Storage:	+4°C

Hazard:	HARMFUL.

Handling:	Hygroscopic.

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Product Literature References

On the interaction of gallamine with muscarinic receptor subtypes: A.D. Michel et al.; Eur. J. Pharmacol. 182, 335 (1990), Abstract;

Pharmacologic discrimination between receptor heterogeneity and allosteric interaction: resultant analysis of gallamine and pirenzepine antagonism of muscarinic responses in rat trachea: T. Kenakin & C. Boselli ; J. Pharmacol. Exp. Ther. 250, 944 (1989), Abstract;

Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat: R. Hammer et al.; Life Sci. 38, 1653 (1986), Abstract;

Stabilization of antagonist binding to cardiac muscarinic acetylcholine receptors by gallamine and other neuromuscular blocking drugs: J. Nedoma et al.; J. Pharmacol. Exp. Ther. 236, 219 (1986), Abstract;