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mGluR agonist
ALX-550-178-M001 1 mg 78.00 USD
ALX-550-178-M005 5 mg 367.00 USD
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Selective agonist for group II mGluRs. Inhibits the NADPH-oxidase dependent ROS system.

Product Specification

Alternative Name:LY-314,593, (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
Purity:≥98% (HPLC)
Appearance:Off-white powder.
Solubility:Soluble in water.
Long Term Storage:Ambient
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Product Literature References

Gamma-secretase gene mutations in familial acne inversa: B. Wang, et al.; Science 330, 1065 (2010), Abstract;
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence: O. Gross, et al.; Nature 459, 433 (2009), Abstract;
D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract;
Effect of the group II metabotropic glutamate agonist, 2R,4R-APDC, varies with age, layer, and visual experience in the visual cortex: C.J. Beaver, et al.; J. Neurophysiol. 82, 86 (1999), Abstract;
Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate: T.E. Salt & J.P. Turner; Exp. Brain Res. 121, 181 (1998), Abstract;
Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists: R. Mistry, et al.; Br. J. Pharmacol. 123, 581 (1998), Abstract;
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death: G. Battaglia, et al.; Eur. J. Pharmacol. 356, 271 (1998), Abstract;
Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats: P.J. Atwell, et al.; Brain Res. 787, 286 (1998), Abstract;
Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase: J.A. Monn, et al.; J. Med. Chem. 39, 2990 (1996), Abstract;
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review),
Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4- dicarboxylate: D.D. Schoepp, et al.; Neuropharmacology 34, 843 (1995), Abstract;

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