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Capsazepine

Capsaicin antagonist
 
ALX-550-145-M005 5 mg 96.00 USD
 
ALX-550-145-M025 25 mg 347.00 USD
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Replaces Prod. #: BML-NK101

Analog of capsaicin (Prod. No. BML-EI125-0200) that acts as a capsaicin antagonist. Inhibits resiniferatoxin and capsaicin-induced contractions of guinea pig trachea. Inhibits C-fiber-smooth muscle contractions induced by capsaicin, bradykinin and neurokinin A. Increases intracellular Ca2+ levels.

Product Specification

Alternative Name:N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
 
Formula:C19H21ClN2O2S
 
MW:376.9
 
Source:Synthetic.
 
CAS:138977-28-3
 
Purity:≥97% (HPLC, TLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in methanol, 100% ethanol (25mg/ml) or DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-550-145
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ALX-550-145

Product Literature References

Pharmacological Properties of Propiverine Contribute to Improving Lower Urinary Tract Dysfunctions in Rats with Spinal Cord Injuries: F. Sakakibara, et al.; Drug Res. (Stuttg.) 66, 464 (2016), Application(s): Drugs and treatmnet of rats, Abstract; Full Text
Effect of capsazepine on cytosolic Ca(2+) levels and proliferation of human prostate cancer cells: J.K. Huang, et al.; Toxicol. In Vitro 20, 567 (2006), Abstract;
Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel: H. Yamamura, et al.; J. Biol. Chem. 279, 44483 (2004), Abstract;
Characterization of the human HCN1 channel and its inhibition by capsazepine: C.H. Gill, et al.; Br. J. Pharmacol. 143, 411 (2004), Abstract;
Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h): A.M. Ray, et al.; J. Neurosci. 23, 10146 (2003), Abstract;
Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea: J.L. Ellis & B.J. Undem; J. Pharmacol. Exp. Ther. 268, 85 (1994), Abstract;
The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin: C.S. Walpole, et al.; J. Med. Chem. 37, 1942 (1994), Abstract;
A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens: C.A. Maggi, et al.; Br. J. Pharmacol. 108, 801 (1993), Abstract;
Effects of ruthenium red and capsazepine on C-fibres in the rabbit iris: Z.Y. Wang & R. Håkanson; Br. J. Pharmacol. 110, 1073 (1993), Abstract;
Effects of ruthenium red and capsazepine on C-fibres in the rabbit iris: Z.Y. Hakanson et al.; Br. J. Pharmacol. 110, 1073 (1993), Abstract;
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin: S. Bevan, et al.; Br. J. Pharmacol. 107, 544 (1992), Abstract;
Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro: L. Urban & A. Dray; Neurosci. Lett. 134, 9 (1991), Abstract;

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