Replaces Prod. #: BML-NK101
Analog of capsaicin (Prod. No. BML-EI125-0200) that acts as a capsaicin antagonist. Inhibits resiniferatoxin and capsaicin-induced contractions of guinea pig trachea. Inhibits C-fiber-smooth muscle contractions induced by capsaicin, bradykinin and neurokinin A. Increases intracellular Ca2+ levels.
Product Details
| Alternative Name: | N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide |
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| Formula: | C19H21ClN2O2S |
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| MW: | 376.9 |
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| Source: | Synthetic. |
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| CAS: | 138977-28-3 |
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| Purity: | ≥97% (HPLC, TLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in methanol, 100% ethanol (25mg/ml) or DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pharmacological Properties of Propiverine Contribute to Improving Lower Urinary Tract Dysfunctions in Rats with Spinal Cord Injuries: F. Sakakibara, et al.; Drug Res. (Stuttg.)
66, 464 (2016),
Application(s): Drugs and treatmnet of rats,
Abstract;
Full Text
Effect of capsazepine on cytosolic Ca(2+) levels and proliferation of human prostate cancer cells: J.K. Huang, et al.; Toxicol. In Vitro
20, 567 (2006),
Abstract;
Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel: H. Yamamura, et al.; J. Biol. Chem.
279, 44483 (2004),
Abstract;
Characterization of the human HCN1 channel and its inhibition by capsazepine: C.H. Gill, et al.; Br. J. Pharmacol.
143, 411 (2004),
Abstract;
Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h): A.M. Ray, et al.; J. Neurosci.
23, 10146 (2003),
Abstract;
Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea: J.L. Ellis & B.J. Undem; J. Pharmacol. Exp. Ther.
268, 85 (1994),
Abstract;
The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin: C.S. Walpole, et al.; J. Med. Chem.
37, 1942 (1994),
Abstract;
A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens: C.A. Maggi, et al.; Br. J. Pharmacol.
108, 801 (1993),
Abstract;
Effects of ruthenium red and capsazepine on C-fibres in the rabbit iris: Z.Y. Wang & R. Håkanson; Br. J. Pharmacol.
110, 1073 (1993),
Abstract;
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin: S. Bevan, et al.; Br. J. Pharmacol.
107, 544 (1992),
Abstract;
Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro: L. Urban & A. Dray; Neurosci. Lett.
134, 9 (1991),
Abstract;
