nor-Binaltorphimine . dihydrochloride

Opioid receptor κ inhibitor



ALX-550-111-M001	1 mg	16.00 USD

Highly selective κ-opioid receptor antagonist.

Product Specification

Alternative Name:	nor-BNI . 2HCl

Formula:	C₄₀H₄₃N₃O₆ . 2HCl

MW:	661.8 . 73.0

Purity:	≥96%

Appearance:	Tan solid.

CAS:	105618-26-6

Solubility:	Soluble in ethanol; sonification required.

Long Term Storage:	-20°C

Use/Stability:	Aqueous solutions are highly unstable and should be freshly prepared.

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Product Literature References

Differential agonist regulation of the human kappa-opioid receptor: A.D. Blake, et al.; J. Neurochem. 68, 1846 (1997), Abstract;

Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor: P.S. Portoghese, et al.; J. Med. Chem. 37, 1495 (1994), Abstract;

Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat: K.D. Carr, et al.; Life Sci. 45, 1787 (1989), Abstract;

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays: A.E. Takemori, et al.; J. Pharmacol. Exp. Ther. 246, 255 (1988), Abstract;

Binaltorphimine and nor-binaltorphimine, potent and selective kappa- opioid receptor antagonists: P.S. Portoghese, et al.; Life Sci. 40, 1287 (1987), Abstract;