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Tamoxifen . citrate

PKC inhibitor
 
ALX-550-095-G001 1 g 111.00 USD
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Replaces Prod. #: BML-S650

Antiestrogen with anti-cancer activity. Selective protein kinase C (PKC) inhibitor and induces PKC epsilon translocation. Induces apoptosis in estrogen receptor-negative human cancer cell lines.

Product Specification

Alternative Name:(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-ethanamine . citrate
 
Formula:C26H29NO . C6H8O7
 
MW:371.5 . 192.1
 
CAS:54965-24-1
 
MI:14: 9048
 
RTECS:KH2387000
 
Purity:≥99% (Assay)
 
Identity:Determined by IR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in methanol or ethanol; very slightly soluble in water or acetone.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
550-095
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550-095

Product Literature References

Is tamoxifen the Rosetta stone for breast cancer?: V.C. Jordan; J. Natl. Cancer Inst. 95, 338 (2003), Abstract;
Tamoxifen for prevention of breast cancer: R.J. Cersosimo; Ann. Pharmacother. 37, 268 (2003), Abstract;
Tamoxifen: a most unlikely pioneering medicine: V.C. Jordan; Nat. Rev. Drug Discov. 2, 205 (2003), Abstract;
Update on clinical role of tamoxifen: J.R. Benson and V. Pitsinis; Curr. Opin. Obstet. Gynecol. 15, 13 (2003), Abstract;
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells: S. Mandlekar, et al.; Cancer Res. 60, 5995 (2000), Abstract; Full Text
Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes: D.A. Cameron, et al.; Eur. J. Cancer. 36, 845 (2000), Abstract;
Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines: S. Mandlekar, et al.; Cancer Res. 60, 6601 (2000), Abstract; Full Text
Tamoxifen in the treatment of metastatic malignant melanoma: still a controversy? (Review): S. Toma, et al.; Int. J. Oncol. 15, 321 (1999), Abstract;
Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines: C.Ferlini et al.; Br. J. Cancer 79, 257 (1999), Abstract;
Activation of nitric oxide synthase is involved in tamoxifen-induced apoptosis of human erythroleukemia K562 cells: M. Maccarrone, et al.; FEBS Lett. 434, 421 (1998), Abstract;
Antagonist effect of insulin-like growth factor I on protein kinase inhibitor-mediated apoptosis in human glioblastoma cells in association with bcl-2 and bcl-xL: S.A. Toms et al.; J. Neurosurg. 88, 884 (1998), Abstract;
Recent advances in understanding the molecular mechanisms of tamoxifen action: Z.Y. Friedman; Cancer Invest. 16, 391 (1998), Abstract;
Steroidal and nonsteroidal oestrogen antagonists in breast cancer: basic and clinical appraisal: R.E. Favoni & A. de Cupis; TIPS 19, 406 (1998), (Review), Abstract;
Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF-7 human breast cancer cells: Y. Lavie et al.; Int. J. Cancer. 77, 928 (1998), Abstract;
Genomic effects of tamoxifen: J.A. Kellen; Anticancer Res. 16, 3537 (1996), Abstract;
Tamoxifen: teaching an old drug new tricks?: D.J. Grainge & J.C. Metcalfe; Nat. Med. 2, 381 (1996), (Review), Abstract;
Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines: W.T. Couldwell, et al.; FEBS Lett. 345, 43 (1994), Abstract;
Signalling targets for anticancer drug development: G. Powis; TIPS 12, 188 (1991), (Review), Abstract;
Opposite effects of tamoxifen on in vitro protein kinase C activity and endogenous protein phosphorylation in intact MCF-7 cells: M. Issandou, et al.; Cancer Res. 50, 5845 (1990), Abstract;
Inhibition of protein kinase C by tamoxifen: C.A. O'Brian, et al.; Cancer Res. 45, 2462 (1985), Abstract;

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