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L-CCG-I

mGluR agonist
 
ALX-550-080-M001 1 mg 41.00 USD
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Potent group II mGluR agonist.

Product Specification

Alternative Name:(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine, (2S,3S,4S)-CCG
 
Formula:C6H9NO4
 
MW:159.1
 
CAS:117857-93-9
 
Purity:≥97%
 
Appearance:White solid.
 
Solubility:Soluble in dilute aqueous base.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light.
 
ALX-550-080
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ALX-550-080

Product Literature References

Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract;
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes: I. Brabet, et al.; Neuropharmacology 37, 1043 (1998), Abstract;
Syntheses and conformational analyses of glutamate analogs: 2-(2- carboxy-3-substituted-cyclopropyl)glycines as useful probes for excitatory amino acid receptors: K. Shimamoto & Y. Ohfune; J. Med. Chem. 39, 407 (1996), Abstract;
The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists: P.J. Flor, et al.; J. Neurochem. 67, 58 (1996), Abstract;
Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-1: H. Yamashita, et al.; Eur. J. Pharmacol. 289, 387 (1995), Abstract;
Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2: P.J. Flor, et al.; Eur. J. Neurosci. 7, 622 (1995), Abstract;
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins and G. Collingridge; TIPS 15, 333 (1994), (Review), Abstract;
Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells: Y. Hayashi, et al.; Br. J. Pharmacol. 107, 539 (1992), Abstract;
Molecular diversity of glutamate receptors and implications for brain function: S. Nakanishi; Science 258, 597 (1992), Abstract;
(2S,3S,4S) alpha-(carboxycyclopropyl)glycine is a novel agonist of metabotropic glutamate receptors: Y. Nakagawa, et al.; Eur. J. Pharmacol. 184, 205 (1990), Abstract;
A potent metabotropic glutamate receptor agonist: electrophysiological actions of a conformationally restricted glutamate analogue in the rat spinal cord and Xenopus oocytes: M. Ishida, et al.; Brain Res. 537, 311 (1990), Abstract;
Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord: H. Shinozaki, et al.; Br. J. Pharmacol. 98, 1213 (1989), Abstract;

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