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mGluR antagonist
ALX-550-075-M005 5 mg 80.00 USD
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Active isomer of (RS)-MCPG (Prod. No. ALX-550-054). Non selective group I/group II mGluR antagonist.

Product Specification

Alternative Name:(S)-α-Methyl-4-carboxyphenylglycine
Appearance:White solid.
Solubility:Soluble in dilute aqueous base.
Long Term Storage:Ambient
Handling:Protect from light.
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Product Literature References

Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract;
(+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor: N.A. Breakwell, et al.; J. Neurophysiol. 79, 1270 (1998), Abstract;
Inhibition of group I metabotropic glutamate receptors blocks spatial learning in rats: D. Balschun & W. Wetzel; Neurosci. Lett. 249, 41 (1998), Abstract;
The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats: J.H. Kim & P. Vezina; Neuropharmacology 37, 189 (1998), Abstract;
(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo: S.J. Martin & R.G. Morris; Neuropharmacology 36, 1339 (1997), Abstract;
Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist: C. Wilson, et al.; Acta. Crystallogr. C 53 ( Pt 7), 909 (1997), Abstract;
Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning: F. Bordi, et al.; Neuropharmacology 35, 1557 (1996), Abstract;
Stereoselective Synthesis of (S)-(+)-alpha-M4CPG, a Selective Antagonist of Metabotropic Glutamate Receptors: M. Dawei & T. Hongqi; Tetrahydron Assym. 7, 1567 (1996),
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996), Abstract;
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review),
Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes: A.E. Kingston, et al.; Neuropharmacology 34, 887 (1995), Abstract;
Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors: M. Kemp, et al.; Eur. J. Pharmacol. 266, 187 (1994), Abstract;
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review), Abstract;
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones: D.E. Jane, et al.; Neuropharmacology 32, 725 (1993), Abstract;

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