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R-(+)-Baclofen . hydrochloride

GABAB receptor agonist
 
ALX-550-074-M050 50 mg 129.00 USD
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Selective GABAB receptor agonist. Skeletal muscle relaxant. The more active enantiomer of (±)-Baclofen (Prod. No. BML-EA128).

Product Specification

Alternative Name:R-(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid . HCl, R-(+)-4-Amino-3-(4-chlorophenyl)butanoic acid . HCl
 
Formula:C10H12ClNO2 . HCl
 
MW:213.7 . 36.5
 
CAS:63701-55-3
 
MI:14: 937
 
RTECS:MW5084350
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water, dilute aqueous base or DMSO.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
550-074
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550-074

Product Literature References

A novel cause of intrathecal baclofen overdosage: lessons to be learnt: C. Dalton, et al.; Clin. Rehabil. 22, 188 (2008), Abstract;
Skeletal muscle relaxants: S. See & R. Ginzburg; Pharmacotherapy 28, 207 (2008), Abstract;
Effects of GABA(B) receptor ligands in animal tests of depression and anxiety: M. Frankowska, et al.; Pharmacol. Rep. 59, 645 (2007), Abstract;
Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat: Y.G. Hong & J.L. Henry; Eur. J. Pharmacol. 196, 267 (1991), Abstract;
Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations: E. Falch, et al.; J. Neurochem. 47, 898 (1986), Abstract;
3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity: B. Witczuk, et al.; Pol. J. Pharmacol. Pharm. 32, 187 (1980), Abstract;

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