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Kynurenic acid

AMPA/kainate and NMDA receptor antagonist
 
ALX-550-052-G001 1 g 52.00 USD
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Metabolite of tryptophan. Antagonist at both the NMDA and AMPA/kainate receptors. Blocks kainic acid neurotoxicity.

Product Specification

Alternative Name:4-Hydroxyquinoline-2-carboxylic acid
 
Formula:C10H7NO3
 
MW:189.2
 
CAS:492-27-3
 
MI:14: 5327
 
Purity:≥98% (Titration, HPLC)
 
Appearance:Off-white to tan powder.
 
Solubility:Soluble in 1M NaOH (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stock solutions are stable for several days when stored at +4°C.
 
ALX-550-052
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ALX-550-052

Product Literature References

Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev. 10, 55 (1990), Abstract;
The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons: M.J. Peet, et al.; Neuroscience 22, 563 (1987), Abstract;
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid: M.N. Perkins & T.W. Stone; Brain Res. 247, 184 (1982), Abstract;

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