DL-AP3

mGluR antagonist



ALX-550-037-M050	50 mg	26.00 USD

Replaces Prod. #: BML-EA103

Metabotropic glutamate receptor antagonist.

Product Specification

Alternative Name:	DL-2-Amino-3-phosphonopropanoic acid

Formula:	C₃H₈NO₅P

MW:	169.1

Purity:	≥97%

Appearance:	White powder.

CAS:	20263-06-3

Solubility:	Soluble in water (25mg/ml).

Long Term Storage:	+4°C

Handling:	Hygroscopic. Protect from light.

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Product Literature References

Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review), Abstract;

The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase: J.E. Hawkinson, et al.; Eur. J. Pharmacol. 307, 219 (1996), Abstract;

1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons: A.J. Irving, et al.; Eur. J. Pharmacol. 186, 363 (1990), Abstract;

Comparison of excitatory amino acid-stimulated phosphoinositide hydrolysis and N-[3H]acetylaspartylglutamate binding in rat brain: selective inhibition of phosphoinositide hydrolysis by 2-amino-3-phosphonopropionate: D.D. Schoepp & B.G. Johnson; J. Neurochem. 53, 273 (1989), Abstract;

The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982), Abstract;