DL-AP5

NMDA receptor antagonist



ALX-550-034-M005	5 mg	62.00 USD

ALX-550-034-M025	25 mg	248.00 USD

Replaces Prod. #: BML-CA400

Potent and selective NMDA receptor antagonist.

Product Specification

Alternative Name:	DL-2-Amino-5-phosphonopentanoic acid

Identity:	Identity determined by ¹H-NMR.

Formula:	C₅H₁₂NO₅P

MW:	197.1

Purity:	≥99% (HPLC, TLC)

Appearance:	White to off-white powder.

CAS:	76326-31-3

Solubility:	Soluble in 100mM NaOH or 25mM water.

Long Term Storage:	+4°C

Hazard:	IRRITANT.

Handling:	Protect from light.

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Product Literature References

Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev. 10, 55 (1990), Abstract;

Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies and J.C. Watkins; Brain Res. 235, 378 (1982), Abstract;

The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982), Abstract;

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies, et al.; Neurosci. Lett. 21, 77 (1981), Abstract;

Excitatory amino acid transmitters: J.C. Watkins and R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review), Abstract;