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L-AP4

mGluR agonist
 
ALX-550-026-M005 5 mg 88.00 USD
 
ALX-550-026-M025 25 mg 365.00 USD
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Replaces Prod. #: BML-EA102

Selective agonist for group III mGluRs. NMDA agonist. Potent synaptic depressant.

Product Specification

Alternative Name:L(+)-2-Amino-4-phosphonobutanoic acid
 
Formula:C4H10NO5P
 
MW:183.1
 
CAS:23052-81-5
 
Purity:≥97% (HPLC)
 
Appearance:White crystalline powder.
 
Solubility:Soluble in dilute aqueous base.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
ALX-550-026
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Product Literature References

Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract;
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate: Y. Nakajima, et al.; J. Biol. Chem. 268, 11868 (1993), Abstract; Full Text
L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase: C. Thomsen, et al.; Eur. J. Pharmacol. 227, 361 (1992), Abstract;
L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor: P.Q. Trombley and G.L. Westbrook; J. Neurosci. 12, 2043 (1992), Abstract;
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990), Abstract;
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord: J. Davies & J.C. Watkins; Brain Res. 235, 378 (1982), Abstract;
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982), Abstract;
Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex: J.F. Koerner & C.W. Cotman; Brain Res. 216, 192 (1981), Abstract;

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