Agmatine . sulfate

NOS inhibitor. NMDA receptor antagonist.



ALX-550-001-M100	100 mg	14.00 USD

ALX-550-001-M500	500 mg	29.00 USD

Decarboxylation product of L-arginine. Endogenous clonidine-displacing substance in the brain. Putative endogenous neurotransmitter at imidazoline receptors. Antagonist of NMDA receptor. Endogenous inhibitor of nitric oxide synthase (NOS). Antiproliferative by its suppresive effect on polyamine.

Product Specification

Alternative Name:	1-Amino-4-guanidinobutane . sulfate, 4-(Aminobutyl)guanidine . sulfate

Identity:	Identity determined by IR.

Formula:	C₅H₁₄N₄. H₂SO₄

MW:	130.2 . 98.1

Purity:	≥97% (TLC)

Appearance:	White to off-white powder.

CAS:	2482-00-0

MI:	14: 188

Solubility:	Soluble in water (50mg/ml).

Long Term Storage:	-20°C

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Product Literature References

Agmatine signaling: odds and threads: R. Berkels, et al.; Cardiovasc. Drug Rev. 22, 7 (2004), (Review), Abstract;

Agmatine: at the crossroads of the arginine pathways: J. Satriano; Ann. N. Y. Acad. Sci. 1009, 34 (2003), (Review), Abstract;

Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes: S. Regunathan & J.E. Piletz; Ann. N. Y. Acad. Sci. 1009, 20 (2003), Abstract;

Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme: D.R. Demady, et al.; Mol. Pharmacol. 59, 24 (2001), Abstract; Full Text

Agmatine suppresses nitric oxide production in microglia: K. Abe, et al.; Brain Res. 872, 141 (2000), Abstract;

Is agmatine a novel neurotransmitter in brain?: D.J. Reis & S. Regunathan; Trends Pharmacol. Sci. 21, 187 (2000), Abstract;

An emerging role for agmatine: J. Satriano, et al.; Kidney Int. 56, 1252 (1999), (Review), Abstract;

Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine: E. Galea, et al.; Biochem. J. 316, 247 (1996), Abstract; Full Text

Selective inhibition of inducible nitric oxide synthase by agmatine: M. Auguet, et al.; Jpn. J. Pharmacol. 69, 285 (1995), Abstract;

Agmatine: an endogenous clonidine-displacing substance in the brain: G. Li, et al.; Science 263, 966 (1994), Abstract;