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β2-Microglobulin (human), (native)

High purity, native protein used as a target diagnostic marker for cancer or renal failure.
 
ALX-522-461-0100 100 µg 105.00 USD
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Purified native human β2-Microglobulin protein.

Product Specification

MW:~12kDa
 
Source:Purified from urine of patients with chronic renal tubular proteinuria.
 
UniProt ID:P61769
 
Formulation:Liquid. In PBS, pH 7.2, containing 150mM sodium chloride, 1mM EDTA sodium salt and 0.05% sodium azide.
 
Purity:≥95% (SDS-PAGE)
 
Applications:WB
 
Shipping:Blue Ice Not Frozen
 
Short Term Storage:+4°C
 
Long Term Storage:+4°C
 
Scientific Background:Major Histocompatibility Complexes (MHC) are expressed on the cell surface of nucleated cells. MHC-1 is composed of two chains – membrane-bound alpha chain and non-covalently linked Beta-2 Microglobulin (B2M). The complex binds peptides produced from cellular proteolytic activity and presents them on the cell surface for evaluation by Cytotoxic T cells. B2M is necessary for MHC-1 presentation and stability of the peptide binding groove formed by the alpha-2 and alpha-3 domains.
B2M is a diagnostic marker for some cancers and for kidney disease. It can be readily leaked into serum due to the lack of a covalent membrane anchor. Serum B2M is elevated in some inflammatory and lymphoproliferative disorders due to increased rate of synthesis or cell turnover. B2M is readily taken up by the glomerular membrane and is reabsorbed by the proximal tube. The relative levels and ratios of B2M in blood and urine can distinguish cellular activation vs renal disorders, and whether a renal problem is in the glomeruli or renal tubes.
 
ALX-522-461 SDS-PAGE 01
SDS-PAGE Analysis of β-2 Microglobulin. Lane 1: MW Marker, Lane 2: 1 µg, Lane 3: 2 µg, Lane 4: 5 µg.
ALX-522-461 WB 01
Western Blot analysis of β-2 Microglobulin. Lane 1: MW marker, Lane 2: 100 ng, Lane 2, 200 ng, Lane 4, 500 ng. Probed with polyclonal (left) and monoclonal (right) antibodies specific for β-2 Microglobulin.
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ALX-522-461 SDS-PAGE 01 ALX-522-461 WB 01

Product Literature References

Comparative evaluation of four urinary tubular dysfunction markers, with special references to the effects of aging and correction for creatinine concentration: J. Moriguchi, et al.; Toxicol Lett. 143, 279 (2003), Abstract;
Distinct differences in association of MHC class I with endoplasmic reticulum proteins in wild-type, and beta 2-microglobulin- and TAP-deficient cell lines: K.M. Paulsson, et al.; Int Immunol. 13, 1063 (2001), Abstract;
Beta 2-microglobulin: its significance and clinical usefulness: M. Bethea & D.T. Forman; Ann. Clin. Lab. Sci. 20, 163 (1990), Abstract;

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