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PEDF (human), (recombinant)

 
ALX-522-458-C010 10 µg 284.00 USD
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Product Specification

Alternative Name:Pigment epithelium-derived factor, Cell proliferation-inducing gene 35 protein, EPC-1, Serpin F1
 
MW:~47 kDa
 
Source:Expressed in CHO cells. A FLAG®-tag is fused at the C-terminus of human PEDF (aa 20-418).
 
UniProt ID:P36955
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:≤0.1EU/µg purified protein (LAL test, Lonza).
 
Reconstitution:Reconstitute with 100µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Scientific Background:Pigment epithelium-derived factor (PEDF) is a 47 kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and foetal tissues, including brain, spinal cord, plasma, bone, prostate, pancreas, heart and lung. PEDF acts as an angiogenesis inhibitor with neurotrophic, immunomodulation and antitumor properties. It functions as anti-angiogenic agent by counterbalancing the proangiogenic effect of VEGF. PEDF is one of the most abundant proteins released by adipocytes and induces insulin resistance in adipocytes and human skeletal muscle cells. It has been reported that PEDF is sufficient to maintain the self-renewal of pluripotent human embryonic stem cells.
 

General Literature References

Pigment epithelium-derived factor is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells: S. Famulla, et al.; Int. J. Obes. (Lond) 35, 762 (2011), Abstract;
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency: R. Gonzalez, et al.; PNAS 107, 3552 (2010), Abstract; Full Text
Characterization of PEDF: a multi-functional serpin family protein: S. Filleur, et al.; J. Cell Biochem. 106, 769 (2009), Abstract;

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