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Angiocidin (human), (recombinant)

 
ALX-522-451-C010 10 µg 414.00 USD
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Shows sequence similarity with proteasome components and is also being referred to as 26A proteasome regulatory subunit S5A. Shows both matrix and cytoplasmic distribution. It binds to thrombospondin-1 and α2β1 integrin, and it inhibits tumor progression and angiogenesis. Expressed in various types of cancer, such as hepatocellular carcinoma, prostate, lung, bladder and melanoma cancers.

Product Specification

Alternative Name:26S proteasome regulatory subunit S5A, 26S proteasome non-ATPase regulatory subunit 4, Rpn10, Multiubiquitin chain-binding protein, Antisecretory factor 1
 
MW:~50kDa (SDS-PAGE).
 
Source:Produced in E. coli. Human Angiocidin (aa 2-377) is untagged.
 
UniProt ID:O43242
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Lonza).
 
Reconstitution:Reconstitute with 100µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 

General Literature References

The immunomodulatory role of angiocidin, a novel angiogenesis inhibitor: A. Gaurnier-Hausser & G. P. Tuszynski; Curr. Pharm. Des. 15, 1937 (2009), Abstract;
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1: J. Zhou, et al.; J. Cell. Biochem. 92, 125 (2004), Abstract;

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