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Omentin (rat), (recombinant)

 
ALX-522-132-C010 10 µg 425.00 USD
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Product Specification

Alternative Name:Intelectin-1, Endothelial lectin HL-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin
 
MW:~38-40kDa
 
Source:Produced in HEK 293 cells. Rat omentin (aa 20-313) is fused at the N-terminus to a FLAG®-tag.
 
UniProt ID:Q499T8
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Reconstitution:Reconstitute with 100µl sterile water.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Scientific Background:Omentin (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been identified as a visceral fat (or omental fat) depot-specific adipokine. Omentin is a secreted protein of ~38 kDa containing a fibrinogen-related domain. Omentin is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin triggers AKT signalling in the absence of insulin.
 
Technical Info/Product Notes:FLAG is a registered trademark of Sigma-Aldrich Co.
 

General Literature References

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006), Abstract; Full Text
Human homologs of the Xenopus oocyte cortical granule lectin XL35: J.K. Lee, et al.; Glycobiology 11, 65 (2001), Abstract; Full Text
Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall: S. Tsuji, et al.; J. Biol. Chem. 276, 23456 (2001), Abstract; Full Text
Molecular cloning and functional expression of a human intestinal lactoferrin receptor: Y.A. Suzuki, et al.; Biochemistry 40, 15771 (2001), Abstract;

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