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Netrin-4 (human), (recombinant)

 
ALX-522-113-C010 10 µg 205.00 USD
 
ALX-522-113-2010 2x10 µg 389.00 USD
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Product Specification

Alternative Name:β-Netrin, Hepar-derived netrin-like protein
 
MW:~70kDa
 
Source:Produced in HEK 293 cells. Human netrin-4 is fused at the N-terminus to a FLAG®-tag.
 
UniProt ID:Q9HB63
 
Concentration:0.1mg/ml after reconstitution.
 
Formulation:Lyophilized. Contains PBS and 5% trehalose.
 
Purity:≥95% (SDS-PAGE)
 
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
 
Reconstitution:Reconstitute each vial with 100µl sterile distilled water. Resuspended protein should be used immediately upon reconstitution to avoid loss in activity due to non-specific binding to the vial. Further dilutions should be made with medium containing 5% fetal calf serum or 0.5% BSA.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Scientific Background:The netrins (whose name means "one who guides" in Sanskrit) are a family of laminin-related secreted protein. In mice, human and rat, netrin-1, netrin-3/NTL2, netrin-4/b and G-netrins have been cloned. The netrins are involved in axonal guidance, are required for regeneration and maintenance of the central nervous system and have been implicated in the development of mammary gland, lung, pancreas, and blood vessel. Netrin-4 acts during the development and control the migration of neurons, being chemoattractive for some neurons and chemorepellent for others. Netrin-4 is broadly expressed in both neural and non-neural tissues. The role of netrin-4 in guiding neurones is mediated by known netrin-1 receptors: DCC and UNC5H1. Netrin-4 promotes angiogenesis by stimulating proliferation and migration of microvascular endothelial cells to the same extent that vascular endothelial growth factor (VEGF).
 
Technical Info/Product Notes:FLAG is a registered trademark of Sigma-Aldrich Co.
 

General Literature References

Netrins promote developmental and therapeutic angiogenesis: B.D. Wilson, et al.; Science 313, 640 (2006), Abstract;

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