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ST2 (mouse):Fc (human), (recombinant)

ALX-522-107-C050 50 µg 414.00 USD

Product Specification

Alternative Name:IL1RL1, Interleukin-1 receptor-like 1, Interleukin-33 receptor
Source:Produced in CHO cells. Mouse ST2 (aa 27-332) is fused to the Fc portion of human IgG1.
UniProt ID:P14719
Concentration:1mg/ml after reconstitution.
Formulation:Lyophilized. Contains PBS.
Purity:≥95% (SDS-PAGE)
Endotoxin Content:<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Specificity:Binds to mouse and human IL-33.
Application Notes:ELISA: binds to mouse IL-33.
Reconstitution:Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Scientific Background:ST2 is a transmembrane receptor of the IL-1 family member IL-33. It induces the NF-κB pathway upon its activation and is involved in T helper type 2 response driving the production of Th2-associated cytokines. ST2 is predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines.

General Literature References

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005), Abstract;

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